prot_Ecto-sp6_S_contig108.1138.1 (polypeptide) Ectocarpus species6 EcLAC_371

You are viewing a polypeptide, more information available on the corresponding mRNA page

Overview
NamemRNA_Ecto-sp6_S_contig108.1138.1
Unique Nameprot_Ecto-sp6_S_contig108.1138.1
Typepolypeptide
OrganismEctocarpus species6 EcLAC_371 (Ectocarpus species6 EcLAC_371)
Sequence length1288
Homology
BLAST of mRNA_Ecto-sp6_S_contig108.1138.1 vs. uniprot
Match: A0A6H5KYY0_9PHAE (Response regulatory domain-containing protein n=1 Tax=Ectocarpus sp. CCAP 1310/34 TaxID=867726 RepID=A0A6H5KYY0_9PHAE)

HSP 1 Score: 1740 bits (4507), Expect = 0.000e+0
Identity = 970/1158 (83.77%), Postives = 1000/1158 (86.36%), Query Frame = 0
Query:  138 MWRGISSEADSASTTSGSGVEGGDAAGTPAWAWVDVGIAWAIAPAAGGSLQLSLWGSIVPSWLCVTVALAYGLRAEEVALDGDEADGALVLFASLVVCGLSALAVGYQVLWEQARDARTLMALEDSMDFEDHRRRQSAFSELLLRHLVTEPSLHVLEAGVKELFKDARIFVMHSDALEQIQDGVSLLAEYGEKALSGLKNGASELPTPVLEKADMEEILDACLRTTAYLAVSRDHHKVQLDLRVAADVDKSVKTYRLWLSQQMTRACLIHALHPEEDDSVILRVSYARPGLMRVGIEAVWRVAGSRAGGGGSGDDGTSTDQREAPRVLSGWDRDMPAAAWWVRAAALALGGEADYDKSRDREGFHELWFTIPAENVPDDDDLELGTPASARDKATAAAAAAVTGGEGPPAELPDAGASSVLPTRGGSTRSS----RLSEIDKQGEGGVSSTAAGADEERGGLNMTAPRAARRESSRKPSLEPLSSAHKTAGAAGAEAAALPRPGAMAASPTFVNPSPRLSSSAPSSLHGLPAAKKRGTILPAIQDTEISPEGSQTTNVVEFDSDDRARSSRKSVGGAGGTDRNTIGHGYRSSLGGTIVGSSGRGKRVSARPNAPRLEDIRVSRVATDCGFNLHEHANRRPSSAPDPTAAAAAWSGETNSGETTAAASVEATSTPVDQISRSTPNSPKRFAAGGERTSNPRSLSVTVRNLLGTEGGLDKLRESLQEDEANPGKAAAAAEEVRSAMRKTAAAGDKGNVSMHKHEAVARAAGQGAAGMAAARLTSGLFLKRPSSAPSPAAAVTKKASVFGGLVQTLVESNSMNWLGTGKVASNISEEREGDTEDXXXXXXXXXQTLEILLVDPQGLVRWALPRLKERKFFVTVAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVATSIRSMNTSGRAGQEGEELNEPRPSTKLLLHTTSAGSVTFDDLEAFLEEDLVDEYVPHPLDLGTLFDFLKLFEEEDDQYGTRKMSMLLEGGADKSNAATG--------GDSAGQAVSGLVRGLSGKNLSGADLGPQGRPVESGPVTFVARLFGAGRAPXXXXXSMEDVGSTFFSVKGRSSEAHAAAAAAKRPHRVDGGRGASNTRTAGPWRPGLPAVSPGLGAAGDEGGDGVD 1283
            MWRG+SSEA+SA T SGSGVEGGDAAGTPAWAWVDVGIAWAIAPAAGGSLQLSLWGSIVPSWLCVTVALAYGLRAEEVALDGD ADGAL+LFASLVVCGLSALAVGYQVLWEQARDARTLMALEDS+DFEDHRRRQ+AFSELLLRHLVTEPSLHVLEAGVKELFKDARIFV+HSDALEQIQDGVSLLAEYGEKALSGLKNGASELPTPVLEKADMEEILDACLRTTAYLAVSRDHHKVQLDLRVAA+VDKSVK YRLWLSQ MTRACLIHALHP+EDDSVILRVSYARPGLMRVGIEAVWRVAGSR G GGS  DGTS D REAPRVLSGWDRDMPAA WWVRAAALALGGEADYD+SRDREGFHELWFTIPAENVPDDDDLEL TPA ARD ATA                                       RLSEIDK+GE        GADEERGGL+MTAPRAARRESSRKP+LEP+SSA KT GAAGA AAALPRPGAMA SP+FVNPSPRLSSSAPSSLHGLPAAKKRGTILPAIQDT+IS EGSQTT VVEFDSDDRAR SRKSVGGAGGTDR TIGHGYRSSLGGTIVGSSGRG+R SARPN   LEDIR+SRV  DC FN  EHANRR SSAPDPTAAAAAWSGE NSGETTAAASV  TSTPVD+ISRSTPNSPK  AAGGERTS  RSLSVT+RNLLGTEGGLDKLRESLQEDEAN GKAAAAAE VR+AMRKTA  GDKG VSMHKHEAVARAAGQG AGMAAARLTSGLFLKRPSSAPSPAAAVTKKASVFGGLVQTLVESNSMNWLGTGKVASN SEE+ GD  D         Q LE                         VAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVA ++RS+N +GRAGQEGE LNEP+PSTKLLLHTTSAGSV FDDLEAFLEEDLVDEYVPHPLDLGTL DFLKLFEEEDDQYGTRKMS LLEGGADKSN            GDSAGQAVSGLVR LSGKNL+GADLGPQG PVESGPVTFVARLFGAGRAPXXXXXSMEDVGSTFFSVKGRS EAHAAA AAK+PH VD  RGAS+TRTAGPWRPG+PAVSPGLGAAGDEGGDG D
Sbjct:    1 MWRGMSSEAESAGT-SGSGVEGGDAAGTPAWAWVDVGIAWAIAPAAGGSLQLSLWGSIVPSWLCVTVALAYGLRAEEVALDGDGADGALILFASLVVCGLSALAVGYQVLWEQARDARTLMALEDSIDFEDHRRRQAAFSELLLRHLVTEPSLHVLEAGVKELFKDARIFVLHSDALEQIQDGVSLLAEYGEKALSGLKNGASELPTPVLEKADMEEILDACLRTTAYLAVSRDHHKVQLDLRVAANVDKSVKIYRLWLSQ-MTRACLIHALHPDEDDSVILRVSYARPGLMRVGIEAVWRVAGSRTGSGGSWGDGTSADHREAPRVLSGWDRDMPAAVWWVRAAALALGGEADYDRSRDREGFHELWFTIPAENVPDDDDLELETPAGARDTATAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLSEIDKRGEXXXXXXXXGADEERGGLDMTAPRAARRESSRKPTLEPISSAPKT-GAAGAGAAALPRPGAMAVSPSFVNPSPRLSSSAPSSLHGLPAAKKRGTILPAIQDTQISLEGSQTTTVVEFDSDDRARGSRKSVGGAGGTDRTTIGHGYRSSLGGTIVGSSGRGERASARPNVTHLEDIRMSRVVADCDFNPDEHANRRSSSAPDPTAAAAAWSGEANSGETTAAASVATTSTPVDRISRSTPNSPKGLAAGGERTSKRRSLSVTIRNLLGTEGGLDKLRESLQEDEANSGKAAAAAEAVRAAMRKTATGGDKGTVSMHKHEAVARAAGQGTAGMAAARLTSGLFLKRPSSAPSPAAAVTKKASVFGGLVQTLVESNSMNWLGTGKVASNNSEEKGGDAGDSEEDTEESGQALE-------------------------VAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVAAAVRSVNINGRAGQEGEGLNEPQPSTKLLLHTTSAGSVKFDDLEAFLEEDLVDEYVPHPLDLGTLSDFLKLFEEEDDQYGTRKMSALLEGGADKSNGGDSTSTVSKYCGDSAGQAVSGLVRSLSGKNLAGADLGPQGGPVESGPVTFVARLFGAGRAPXXXXXSMEDVGSTFFSVKGRSREAHAAATAAKKPHGVDSERGASSTRTAGPWRPGIPAVSPGLGAAGDEGGDGGD 1130          
BLAST of mRNA_Ecto-sp6_S_contig108.1138.1 vs. uniprot
Match: D7FY83_ECTSI (Response regulatory domain-containing protein n=1 Tax=Ectocarpus siliculosus TaxID=2880 RepID=D7FY83_ECTSI)

HSP 1 Score: 1545 bits (4001), Expect = 0.000e+0
Identity = 842/909 (92.63%), Postives = 850/909 (93.51%), Query Frame = 0
Query:  258 MALEDSMDFEDHRRRQSAFSELLLRHLVTEPSLHVLEAGVKELFKDARIFVMHSDALEQIQDGVSLLAEYGEKALSGLKNGASELPTPVLEKADMEEILDACLRTTAYLAVSRDHHKVQLDLRVAADVDKSVKTYRLWLSQQMTRACLIHALHPEEDDSVILRVSYARPGLMRVGIEAVWRVAGSRAGGGGSGDDGTSTDQREAPRVLSGWDRDMPAAAWWVRAAALALGGEADYDKSRDREGFHELWFTIPAENVPDDDDLELGTPASARDKATAAAAAAV-TGGEGPPAELPDAGASSVLPTRGGST----RSSRLSEIDKQGEGGVSSTAAGADEERGGLNMTAPRAARRESSRKPSLEPLSSAHKTAGAAGAEAAALPRPGAMAASPTFVNPSPRLSSSAPSSLHGLPAAKKRGTILPAIQDTEISPEGSQTTNVVEFDSDDRARSSRKSVGGAGGTDRNTIGHGYRSSLGGTIVGSSGRGKRVSARPNAPRLEDIRVSRVATDCGFNLHEHANRRPSSAPDPTAAAAAWSGETNSGETTAAASVEATSTPVDQISRSTPNSPKRFAAGGERTSNPRSLSVTVRNLLGTEGGLDKLRESLQEDEANPGKAAAAAEEVRSAMRKTAAAGDKGNVSMHKHEAVARAAGQGAAGMAAARLTSGLFLKRPSSAPSPAAAVTKKASVFGGLVQTLVESNSMNWLGTGKVASNISEEREGDTEDXXXXXXXXXQTLEILLVDPQGLVRWALPRLKERKFFVTVAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVATSIRSMNTSGRAGQEGEELNEPRPSTKLLLHTTSAGSVTFDDLEAFLEEDLVDEYVPHPLDLGTLFDFLKLFEEEDDQYGTRKMSMLLEGGADKSNAATGGDS 1161
            MALEDSMDFEDHRRRQSAFSELLLRHLVTEPSLHVLEAGVKELFKDARIFVMHSDALEQIQDGVSLLAEYGEKALSGLKNGASELPTPVLEKADMEEILDACLRTTAYLAVSRDHHKVQLDLRVAADVDKSVKTYRLWLSQ MTRACLIHALHP+EDDSVILRVSYARPGLMRVGIEAVWRVAGSR GG       TS DQREAPRVLSGWDRDMPAAAWWVRAAALALGGEADYD+SRDREGFHELWFTIPAENVPDDDDLEL TP SARD AT        TGGEGPPAELPDAGASSVL TRGGST    RSSRL EIDKQGEG VSSTAAGADEERGGL+MTAPRAARRESSR P+LEPLSSAHKT GA GA AAALPRPGAMAASPTFVNPSPRLSSSAPSSLHGLPAAKKRGTILPAIQDTEIS EGSQTTNV+EFDSDDRARSSRKSVGGAGGTDRNTIGHGYRSSLGGTIVGSSGRGK VSARPN PRLEDIRVSRVATDCGFN  EHANRRPSSAPDPTAAAAAWSGETN GETTAAASV  TSTPVD+ISRS+PNSPKRFAAGGERTS  RSLS+TVRNLLGTEGGLDKLRESLQEDEANPGKAAAAAEEVR AMRKTAAAGDKGNVSMHKHEAVARAAGQGAAGMAAARLTSGLFLKRPSSAPSPAAAVTKKASVFGGLVQTLVESNSMNWLGTGKVASNISEEREGDT D         QTLEILLVDPQGLVRWALPRLKER FFVTVAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVATSIRSMNTSGRAGQEGEELNEP PSTKLLLHTTSAGSVTFDDLEAFLEEDLVDEYVPHPLDLGTLFDFLKLFEEEDDQYGTRKMS LLEGGADKSN   GGDS
Sbjct:    1 MALEDSMDFEDHRRRQSAFSELLLRHLVTEPSLHVLEAGVKELFKDARIFVMHSDALEQIQDGVSLLAEYGEKALSGLKNGASELPTPVLEKADMEEILDACLRTTAYLAVSRDHHKVQLDLRVAADVDKSVKTYRLWLSQ-MTRACLIHALHPDEDDSVILRVSYARPGLMRVGIEAVWRVAGSREGGXXXXXXXTSADQREAPRVLSGWDRDMPAAAWWVRAAALALGGEADYDRSRDREGFHELWFTIPAENVPDDDDLELDTPVSARDTATXXXXXXXXTGGEGPPAELPDAGASSVLSTRGGSTSGRTRSSRLGEIDKQGEGSVSSTAAGADEERGGLDMTAPRAARRESSRNPTLEPLSSAHKT-GATGAGAAALPRPGAMAASPTFVNPSPRLSSSAPSSLHGLPAAKKRGTILPAIQDTEISLEGSQTTNVMEFDSDDRARSSRKSVGGAGGTDRNTIGHGYRSSLGGTIVGSSGRGKSVSARPNVPRLEDIRVSRVATDCGFNPDEHANRRPSSAPDPTAAAAAWSGETNIGETTAAASVATTSTPVDRISRSSPNSPKRFAAGGERTSKRRSLSITVRNLLGTEGGLDKLRESLQEDEANPGKAAAAAEEVRGAMRKTAAAGDKGNVSMHKHEAVARAAGQGAAGMAAARLTSGLFLKRPSSAPSPAAAVTKKASVFGGLVQTLVESNSMNWLGTGKVASNISEEREGDTGDSEEDTEESEQTLEILLVDPQGLVRWALPRLKERNFFVTVAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVATSIRSMNTSGRAGQEGEELNEPGPSTKLLLHTTSAGSVTFDDLEAFLEEDLVDEYVPHPLDLGTLFDFLKLFEEEDDQYGTRKMSALLEGGADKSN---GGDS 904          
BLAST of mRNA_Ecto-sp6_S_contig108.1138.1 vs. uniprot
Match: UPI001298435A (response regulator n=1 Tax=Roseimaritima sediminicola TaxID=2662066 RepID=UPI001298435A)

HSP 1 Score: 55.1 bits (131), Expect = 3.240e-5
Identity = 31/92 (33.70%), Postives = 50/92 (54.35%), Query Frame = 0
Query:  988 ILLVDPQGLVRWALPRLKERKFF-VTVAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVATSIRSMNTSGRAGQEGEELN 1078
            +L+ D    +R +L    ER+ F VT+A   +EA+D++      +A+VD+HMPR+SG +   R+R  ELEV   + S         E E ++
Sbjct:    5 LLITDDDEALRLSLGEAFERRGFQVTLAADGQEALDVVHSATIHMALVDVHMPRVSGLQLIERLRGDELEVPCILMSAALDESIRHEAESMH 96          
BLAST of mRNA_Ecto-sp6_S_contig108.1138.1 vs. uniprot
Match: A0A3N5TLZ4_9DELT (Response regulator n=2 Tax=Desulfobacteraceae bacterium TaxID=2049433 RepID=A0A3N5TLZ4_9DELT)

HSP 1 Score: 54.7 bits (130), Expect = 5.080e-5
Identity = 35/92 (38.04%), Postives = 52/92 (56.52%), Query Frame = 0
Query:  984 QTLEILLVDPQGLVRWALP-RLKERKFFVTVAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRVRAHELEVATSIRSMNTSGRAGQEG 1074
            + + +LLVD +   R  L  RLK R   VT A S EEA+++I +  + VA+VD+ MP M G E  RR+R  +  +   + + + S  AG EG
Sbjct:    2 KNISLLLVDDEDDFRTTLANRLKRRNLDVTDAGSGEEAIEIIGQKSFDVAIVDIKMPGMDGIETLRRIRKIDPLLEVILLTGHASVEAGIEG 93          
The following BLAST results are available for this feature:
BLAST of mRNA_Ecto-sp6_S_contig108.1138.1 vs. uniprot
Analysis Date: 2022-09-16 (Diamond blastp: OGS1.0 vs UniRef90)
Total hits: 4
Match NameE-valueIdentityDescription
A0A6H5KYY0_9PHAE0.000e+083.77Response regulatory domain-containing protein n=1 ... [more]
D7FY83_ECTSI0.000e+092.63Response regulatory domain-containing protein n=1 ... [more]
UPI001298435A3.240e-533.70response regulator n=1 Tax=Roseimaritima sediminic... [more]
A0A3N5TLZ4_9DELT5.080e-538.04Response regulator n=2 Tax=Desulfobacteraceae bact... [more]
back to top
InterPro
Analysis Name: InterProScan on OGS1.0
Date Performed: 2022-09-29
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001789Signal transduction response regulator, receiver domainSMARTSM00448REC_2coord: 986..1127
e-value: 1.8E-8
score: 44.2
IPR001789Signal transduction response regulator, receiver domainPFAMPF00072Response_regcoord: 988..1066
e-value: 1.5E-7
score: 31.6
IPR001789Signal transduction response regulator, receiver domainPROSITEPS50110RESPONSE_REGULATORYcoord: 987..1131
score: 19.974
NoneNo IPR availableGENE3D3.40.50.2300coord: 971..1141
e-value: 3.5E-14
score: 54.4
NoneNo IPR availablePANTHERPTHR23202WASP INTERACTING PROTEIN-RELATEDcoord: 80..1281
NoneNo IPR availablePHOBIUSCYTOPLASMIC_DOMAINCytoplasmic domaincoord: 211..221
NoneNo IPR availablePHOBIUSNON_CYTOPLASMIC_DOMAINNon cytoplasmic domaincoord: 140..190
NoneNo IPR availablePHOBIUSTRANSMEMBRANETransmembrane regioncoord: 62..83
NoneNo IPR availablePHOBIUSTRANSMEMBRANETransmembrane regioncoord: 95..114
NoneNo IPR availablePHOBIUSTRANSMEMBRANETransmembrane regioncoord: 121..139
NoneNo IPR availablePHOBIUSCYTOPLASMIC_DOMAINCytoplasmic domaincoord: 1..61
NoneNo IPR availablePHOBIUSNON_CYTOPLASMIC_DOMAINNon cytoplasmic domaincoord: 249..1287
NoneNo IPR availablePHOBIUSTRANSMEMBRANETransmembrane regioncoord: 191..210
NoneNo IPR availablePHOBIUSTRANSMEMBRANETransmembrane regioncoord: 222..248
NoneNo IPR availablePHOBIUSNON_CYTOPLASMIC_DOMAINNon cytoplasmic domaincoord: 84..94
NoneNo IPR availablePHOBIUSCYTOPLASMIC_DOMAINCytoplasmic domaincoord: 115..120
NoneNo IPR availableTMHMMTMhelixcoord: 61..82
NoneNo IPR availableTMHMMTMhelixcoord: 190..212
NoneNo IPR availableTMHMMTMhelixcoord: 121..143
NoneNo IPR availableTMHMMTMhelixcoord: 225..247
NoneNo IPR availableTMHMMTMhelixcoord: 92..114
IPR011006CheY-like superfamilySUPERFAMILY52172CheY-likecoord: 986..1128

Alignments
The following features are aligned
Aligned FeatureFeature TypeAlignment Location
Ecto-sp6_S_contig108contigEcto-sp6_S_contig108:176752..192990 -
Analyses
This polypeptide is derived from or has results from the following analyses
Analysis NameDate Performed
InterProScan on OGS1.02022-09-29
Diamond blastp: OGS1.0 vs UniRef902022-09-16
Ectocarpus species6 EcLAC_371 OGS1.02022-07-08
Relationships

This polypeptide derives from the following mRNA feature(s):

Feature NameUnique NameSpeciesTypePosition
mRNA_Ecto-sp6_S_contig108.1138.1mRNA_Ecto-sp6_S_contig108.1138.1Ectocarpus species6 EcLAC_371mRNAEcto-sp6_S_contig108 176752..192990 -


Sequences
The following sequences are available for this feature:

polypeptide sequence

>prot_Ecto-sp6_S_contig108.1138.1 ID=prot_Ecto-sp6_S_contig108.1138.1|Name=mRNA_Ecto-sp6_S_contig108.1138.1|organism=Ectocarpus species6 EcLAC_371|type=polypeptide|length=1288bp
MHPHATDGTSQTENNGPGSAAAIDDKRPSTGSQHRISRLRATLVEPIAQA
KQDRLAVTRRVALSRVLSVFLVASTAASCLLLQRSGLVDLALGRISVAII
GLFWFMSTFTQAFLRDTRRACNGISLLCFIVWSLSHIMWRGISSEADSAS
TTSGSGVEGGDAAGTPAWAWVDVGIAWAIAPAAGGSLQLSLWGSIVPSWL
CVTVALAYGLRAEEVALDGDEADGALVLFASLVVCGLSALAVGYQVLWEQ
ARDARTLMALEDSMDFEDHRRRQSAFSELLLRHLVTEPSLHVLEAGVKEL
FKDARIFVMHSDALEQIQDGVSLLAEYGEKALSGLKNGASELPTPVLEKA
DMEEILDACLRTTAYLAVSRDHHKVQLDLRVAADVDKSVKTYRLWLSQQM
TRACLIHALHPEEDDSVILRVSYARPGLMRVGIEAVWRVAGSRAGGGGSG
DDGTSTDQREAPRVLSGWDRDMPAAAWWVRAAALALGGEADYDKSRDREG
FHELWFTIPAENVPDDDDLELGTPASARDKATAAAAAAVTGGEGPPAELP
DAGASSVLPTRGGSTRSSRLSEIDKQGEGGVSSTAAGADEERGGLNMTAP
RAARRESSRKPSLEPLSSAHKTAGAAGAEAAALPRPGAMAASPTFVNPSP
RLSSSAPSSLHGLPAAKKRGTILPAIQDTEISPEGSQTTNVVEFDSDDRA
RSSRKSVGGAGGTDRNTIGHGYRSSLGGTIVGSSGRGKRVSARPNAPRLE
DIRVSRVATDCGFNLHEHANRRPSSAPDPTAAAAAWSGETNSGETTAAAS
VEATSTPVDQISRSTPNSPKRFAAGGERTSNPRSLSVTVRNLLGTEGGLD
KLRESLQEDEANPGKAAAAAEEVRSAMRKTAAAGDKGNVSMHKHEAVARA
AGQGAAGMAAARLTSGLFLKRPSSAPSPAAAVTKKASVFGGLVQTLVESN
SMNWLGTGKVASNISEEREGDTEDSEEDSEESEQTLEILLVDPQGLVRWA
LPRLKERKFFVTVAHSAEEAMDMILEGYYQVAVVDLHMPRMSGTEFCRRV
RAHELEVATSIRSMNTSGRAGQEGEELNEPRPSTKLLLHTTSAGSVTFDD
LEAFLEEDLVDEYVPHPLDLGTLFDFLKLFEEEDDQYGTRKMSMLLEGGA
DKSNAATGGDSAGQAVSGLVRGLSGKNLSGADLGPQGRPVESGPVTFVAR
LFGAGRAPPPPPPSMEDVGSTFFSVKGRSSEAHAAAAAAKRPHRVDGGRG
ASNTRTAGPWRPGLPAVSPGLGAAGDEGGDGVDDRGG*
back to top
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001789Sig_transdc_resp-reg_receiver
IPR011006CheY-like_superfamily