prot_L-elsbetiae_contig733.16203.1 (polypeptide) Laminarionema elsbetiae ELsaHSoW15

You are viewing a polypeptide, more information available on the corresponding mRNA page

Overview
NamemRNA_L-elsbetiae_contig733.16203.1
Unique Nameprot_L-elsbetiae_contig733.16203.1
Typepolypeptide
OrganismLaminarionema elsbetiae ELsaHSoW15 (Laminarionema elsbetiae ELsaHSoW15)
Sequence length482
Homology
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A6H5L2B5_9PHAE (Uncharacterized protein n=1 Tax=Ectocarpus sp. CCAP 1310/34 TaxID=867726 RepID=A0A6H5L2B5_9PHAE)

HSP 1 Score: 442 bits (1138), Expect = 4.840e-149
Identity = 202/295 (68.47%), Postives = 235/295 (79.66%), Query Frame = 0
Query:   76 VEQLRVLVPLYARPEGDFWKFMVESGHNSTVSFSVVINPNSGPGDSPEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLCGGYFFDEGPGLEEGTWKYTDYYSHVQAVSGPGSTVVINPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEEFLEWTVFQLFCANWGYVFFTDDSFGEDGNPWDELPSYFAQLLAAAAKAPESAGECGTFAPXXXXXXXXXXXXLAPGETRPPLP 370
            VEQLRVL PLYARPE +FW  MV++  N+TVS+SVVINP+SGPGDS EE YTTG+ +L+  GVEVLCYVPTGFG+TDV TVTAD+D YESFYP +C G+FFDEGPG E+  WKYTDYY+HVQ V G GSTVV+NPGI PH+SLY + D YA  NP  GGQ+V+TS+EN F RFYDGSQD+ N EVPFPPRY+ DRY HS +VYAAYF TL+EFL+WTV QL+CANWGYVFFTDDSFG+D NPWDE+P YF +LL + AKA E A  CGT+AP            LAPGETR P+P
Sbjct:   70 VEQLRVLAPLYARPEDEFWSLMVDAAQNTTVSYSVVINPSSGPGDSAEEAYTTGITELLNVGVEVLCYVPTGFGSTDVSTVTADVDKYESFYPGMCDGFFFDEGPGGEDNAWKYTDYYNHVQEVGGEGSTVVVNPGIRPHDSLYFIGDVYAGTNPGQGGQVVITSYENSFPRFYDGSQDYHNQEVPFPPRYITDRYKHSIMVYAAYFTTLQEFLDWTVLQLYCANWGYVFFTDDSFGDDENPWDEMPGYFMELLESVAKAEEGAEGCGTWAPTAAPTPIPTLAPLAPGETRAPVP 364          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: D7FXS0_ECTSI (Uncharacterized protein n=1 Tax=Ectocarpus siliculosus TaxID=2880 RepID=D7FXS0_ECTSI)

HSP 1 Score: 299 bits (766), Expect = 9.730e-97
Identity = 135/191 (70.68%), Postives = 157/191 (82.20%), Query Frame = 0
Query:   97 MVESGHNSTVSFSVVINPNSGPGDSPEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLCGGYFFDEGPGLEEGTWKYTDYYSHVQAVSGPGSTVVINPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEE 287
            MVE+  N+TVS+SVVINP+SGPGDS EE YTTG+ +L+  GVEVLCYVPTGFG+TDV TVTADID YESFYP +C GYFFDEGPG E+  WKYTDYY+HVQ   G GSTVV+NPGI PH+SLY + D YA  NP  GGQ+V+TS+EN F +FYDGSQD+ N EVPFPPRY+ DRY HS +VYAAYF TL+E
Sbjct:    1 MVEAAQNTTVSYSVVINPSSGPGDSAEEAYTTGITELLNVGVEVLCYVPTGFGSTDVSTVTADIDKYESFYPGMCDGYFFDEGPGGEDNAWKYTDYYNHVQEAGGAGSTVVVNPGIRPHDSLYFIGDVYAGTNPGQGGQVVITSYENSFPKFYDGSQDYHNQEVPFPPRYVTDRYKHSVMVYAAYFTTLQE 191          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: SR4_PHYPO (Spherulin-4 n=1 Tax=Physarum polycephalum TaxID=5791 RepID=SR4_PHYPO)

HSP 1 Score: 99.0 bits (245), Expect = 3.290e-19
Identity = 65/171 (38.01%), Postives = 92/171 (53.80%), Query Frame = 0
Query:   59 LLMMGLAACT-CRVSAQPVEQLRVLVPLYARPEGDFWKFMVESGHNSTVSFSVVINPNSGPGDS-PEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLCGGYFFDEGPGLEEGTWKYTDYYSHVQAVSGPGSTVVINPGIPPHESLYNVADRYAI 227
            LL++  A  T   ++A   E +++LVPLY  P G  W   V +   + V    +INPNSGP  S P+  YTT MN L  AGV+++ YV T +G   V  V ADIDTY S YP L G  F DE          YT+ Y+H+++ SG  +++ +NPG  P +    ++    I
Sbjct:   76 LLLLARAPLTYVHITATSSEPIKLLVPLYVYP-GAAWD-SVANAAKTGVKIIAIINPNSGPASSGPDSSYTTYMNKLTAAGVDMVGYVHTSYGARAVGDVNADIDTYASKYPGLKG-IFLDEASASASEISYYTNVYNHIKSKSGYVNSI-LNPGTQPDQGYLAISSNIVI 242          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A8K0UW06_9AGAM (Spherulation-specific family 4-domain-containing protein n=1 Tax=Cristinia sonorae TaxID=1940300 RepID=A0A8K0UW06_9AGAM)

HSP 1 Score: 98.2 bits (243), Expect = 3.740e-19
Identity = 86/266 (32.33%), Postives = 117/266 (43.98%), Query Frame = 0
Query:   81 VLVPLYARPEGD-----FWKFMVES-GHNSTVSFSVVINPNSGPGDS--PEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLC-GGYFFDEGPGLEEGTWKYTDYYSHV-QAVSGPGSTVVINPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEEFLEWTVFQLFCANW-GYVFFTDDSFGEDGNPWDELPSYFAQLLAAAAKA 335
            ++VPLY  P GD      W  ++ S      + F V+INPNSGPG +  P+  Y + +  L    VE++ YVPTGFG+     VTADI+TY  +       G FFDE  G      KYT Y SH  Q + G    V +NPG  P    + +AD             +V + E+ F  F        +      P   Q   LH A       A     +     QL   +  G ++ TDD    +GNP+D LPS  A  ++A A A
Sbjct:   62 IIVPLYIFP-GDPGICASWTPLINSITAQPNLRFHVIINPNSGPGTTAQPDASYQSCVAKLKHPNVELVGYVPTGFGSRAQSAVTADINTYAGWASAYALDGIFFDEVSGTAGDLGKYTTYVSHARQVLKGGSGAVTLNPGAQPTAGYFGIAD-------------LVATREDFFNDFSPSQLTLGSST----PANKQAVILHDAPS-----APPSSIIS----QLVATDRIGALYITDDVQANNGNPYDSLPSDLAAFVSAVAAA 300          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A522XYQ4_9ARCH (Uncharacterized protein n=1 Tax=Candidatus Nitrosotenuis sp. TaxID=2507556 RepID=A0A522XYQ4_9ARCH)

HSP 1 Score: 99.4 bits (246), Expect = 1.440e-18
Identity = 80/253 (31.62%), Postives = 119/253 (47.04%), Query Frame = 0
Query:   81 VLVPLYARPEGDFWKFMVESGH-NSTVSFSVVINPNSGPGDSPEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLCGGYFFDEGPGLEEGTWKYTDYYSHVQAVSGPGSTVVINPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEEFLEWTVFQLFCANW-GYVFFTDDSFGEDGNPWDELPSYFAQLLAA 331
            +++PLY  P G  W  +V + + + +V    +INPN+GPG + +  Y +G+  L  AG+ V+ YV TG+G+    TV +DIDTY+S+YPQL G +F +   G  + T+ Y +  +H ++V    +  V NPG     S     D   I      G L   SF   +   YD S                     S L Y     TL+     T F    AN+  Y++ T+D+     NPWD +  YF+ L AA
Sbjct:   39 IMIPLYTYP-GTTWDTVVAAKNAHPSVPIVAIINPNNGPGGAKDSNYVSGIQKLQSAGIVVIGYVATGYGSRSTSTVNSDIDTYKSWYPQLQGIFFDEMSNGGGDETY-YGNLSNHSKSVGF--AFTVGNPGAETQSSYIGTMDNIIIYET---GGLPSLSFLGGWHTGYDKSN-------------------FSYLSYGV--GTLD-----TSFVQSSANYVSYMYITNDNLS---NPWDSVTPYFSDLAAA 255          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A1Q7L1P0_9ARCH (Fibronectin type-III domain-containing protein (Fragment) n=4 Tax=unclassified Thaumarchaeota TaxID=1104572 RepID=A0A1Q7L1P0_9ARCH)

HSP 1 Score: 95.9 bits (237), Expect = 1.650e-17
Identity = 81/254 (31.89%), Postives = 110/254 (43.31%), Query Frame = 0
Query:   81 VLVPLYARPEGDFWKFMVESGHNSTVSFSVVINPNSGPGDSPEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLCGGYFFDE---GPGLEEGTWKYTDYYSHVQAVSGPGSTVVI-NPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEEFLEWTVFQLFCANWGYVFFTDDSFGEDGNPWDELPSYFAQLLA 330
            V+VPLY  P+  +         + +V    +INPN+GPG S +  Y TG+  L  AGV VL YV TG+G+    +V ADIDTY+S+Y     G FFDE    PG E      + YY+  Q     G T  + NPG     S     D   I     GG   ++S    +   YD S +F  +        +   +L S   Y                       GY + T+D+     NPWD +P YFA L+A
Sbjct:   38 VIVPLYTYPDSTWDTVAQAKIAHPSVPVVAIINPNNGPGSSKDANYVTGIQKLHSAGVVVLGYVATGYGSRSTGSVDADIDTYKSWYS--LNGIFFDEMSNAPGDE------SHYYNLSQYAKSQGLTFTVGNPGTDTLTSYIGTVDNIVIYET--GGLPSISSLGGWYTN-YDKS-NFSTLSYGVGT--ISQSFLTSESSYV----------------------GYTYITNDNLP---NPWDSVPPYFATLVA 252          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A074XJD8_AURPU (Uncharacterized protein n=17 Tax=Aureobasidium pullulans TaxID=5580 RepID=A0A074XJD8_AURPU)

HSP 1 Score: 89.7 bits (221), Expect = 1.280e-16
Identity = 64/210 (30.48%), Postives = 100/210 (47.62%), Query Frame = 0
Query:   79 LRVLVPLYARPEGDFWKFMVES-GHNSTVSFSVVINPNSGPGDSPEEV-YTTGMNDLIE-AGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQ-----LCGGYFFDEGPGLEEGTWKYTDY------YSHVQAVSGPGSTVVINPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHS 274
            + V +PLY  P    W+ + ++  +N +V+F V+INPNSGPG SP +  Y  G++ +   + V ++ YV T +G   +  + ADIDTY+S+           G F DE P        Y DY      Y+ V+     G+ V  NPG+P   S YN+AD             ++ ++EN ++   D   +  N  +P P R      +HS
Sbjct:    5 MHVALPLYVYPSSGAWQPLYDAVTNNPSVTFDVIINPNSGPGGSPPDSNYIAGVSKINSYSNVNMVGYVHTSYGDRALSDIEADIDTYQSWSTYSNANIALKGIFVDETPA------SYNDYNYMNTIYNKVKNTMTHGNLVWTNPGVPVDSSFYNIAD-------------MINAYENTYD---DWINNGGNTSIPVPLRSQSTVLIHS 192          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A533WNY1_9ARCH (Uncharacterized protein n=1 Tax=Thaumarchaeota archaeon TaxID=2026795 RepID=A0A533WNY1_9ARCH)

HSP 1 Score: 92.8 bits (229), Expect = 3.030e-16
Identity = 87/302 (28.81%), Postives = 131/302 (43.38%), Query Frame = 0
Query:   33 LSSRRIHGSMLTRKNNEPGMQAPVAMLLMMGLAACTCRVSAQPVEQLRVLVPLYARPEGDFWKFMVESGHNSTVSFSVVINPNSGPGDSPEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLCGGYFFDE---GPGLEEGTWKYTDYYSHVQAVSGPGSTVVI-NPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEEFLEWTVFQLFCANWGYVFFTDDSFGEDGNPWDELPSYFAQLLA 330
            LS RR + + L +K++   +   +++L+++ +   +    A       V+VPLY  P+            + +V    +INP++GPG S +  Y TG+  L  AGV VL YV TG+G+    +V ADIDTY+++Y     G FFDE    PG E      + YY+  Q     G T  + NPG     S     D   I     GG   ++S    +   YD S +F  +        +   +L S   Y                       GY + T+D+     NPWD +P YFA L+A
Sbjct:   44 LSRRRFYYNNLIKKSSGKFVWI-LSILMIISVPLLSSSHYALAATTTGVIVPLYTYPDSTCDTVAQAKIAHPSVPVVAIINPDNGPGSSKDANYVTGIQKLHSAGVVVLGYVYTGYGSRSANSVNADIDTYKNWYS--LNGIFFDEMSNAPGDE------SHYYNLSQYAKSQGLTFTVGNPGTDTLSSYIGTVDNIVIYET--GGLPSISSLGGWYTN-YDKS-NFSTLSYGVGT--ISQSFLTSESSYV----------------------GYTYITNDNLP---NPWDSVPPYFATLVA 305          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A1Q7X933_9ARCH (Uncharacterized protein (Fragment) n=1 Tax=Thaumarchaeota archaeon 13_1_20CM_2_38_5 TaxID=1805380 RepID=A0A1Q7X933_9ARCH)

HSP 1 Score: 87.8 bits (216), Expect = 1.870e-15
Identity = 80/277 (28.88%), Postives = 118/277 (42.60%), Query Frame = 0
Query:   56 VAMLLMMGLAACTCRVSAQPVEQLRVLVPLYARPEGDFWKFMVESGHNSTVSFSVVINPNSGPGDSPEEVYTTGMNDLIEAGVEVLCYVPTGFGTTDVPTVTADIDTYESFYPQLCGGYFFDEGPGLEEGTWKYTDYYSHV-QAVSGPGSTVVI-NPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEEFLEWTVFQLFCANWGYVFFTDDSFGEDGNPWDELPSYFAQLLA 330
            + M++ + L   T   SA       VLVPLY  P+  +         + +V    +INPN+GPG S +  Y +G+  L  AGV V+ YV TG+G+    ++ ADI++Y+++Y     G FFDE            +YYS++ Q     G T  + NPG     S     D   I     GG   ++S    +   YD S +F  +        L   +L S   Y                       GY + T+D+     NPWD +PSYF  L+A
Sbjct:   15 ILMIISVPLLLSTHHASAATTTG--VLVPLYTYPDSSWDTVTQAKTAHPSVPIVAIINPNNGPGSSKDANYVSGIQKLQSAGVVVIGYVYTGYGSRSTSSIDADINSYKNWYSP--NGIFFDEMSNAAGDE----NYYSNLSQYAKSQGLTFTVGNPGTDTLSSYIGTVDNIVIYES--GGLPSISSLGGWYTS-YDKS-NFSTLSYGVST--LSQSFLTSESSYV----------------------GYTYVTNDNLP---NPWDSVPSYFGTLVA 252          
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Match: A0A1Y1QAK3_9GAMM (Uncharacterized protein n=1 Tax=Thiothrix lacustris TaxID=525917 RepID=A0A1Y1QAK3_9GAMM)

HSP 1 Score: 89.4 bits (220), Expect = 3.430e-15
Identity = 83/275 (30.18%), Postives = 120/275 (43.64%), Query Frame = 0
Query:   78 QLRVLVPLYARPE-----GDFWKFMVESGHNSTVSFSVVINPNSGPGDS--PEEVYTTGMNDLIEAGVEVLCYVPTGFG----------TTDVPTVTADIDTYESFYPQLCGGYFFDEGPGLEEGTWKYTDYYSHVQAVSGPGSTVVINPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYDGSQDFRNMEVPFPPRYLQDRYLHSA--LVYA----AYFATLEEFLEWTVFQLFCANWGYVFFTDDSFGEDGNPWDELPSYFAQLL 329
            +L +L+PLY  P         W  +  +   S V  + +INP +GPG S  P   Y TGM  L  AGV +L YVPT +G          T  V  +  DI+ Y   +     G FFDE          Y +  +H +++  P   +V+NPGI P  S         + N  +    V   FE+ +  +    +         P  + Q      +  LVY     A  A +++ L+W        N+GY++FTDD  G DGNPWD LP+Y+  LL
Sbjct:  247 RLSILLPLYTYPSHWNANSYIWDDVAAA--QSKVDITAIINPANGPGASGTPNRDYQTGMQALRTAGVTMLGYVPTCWGNSQPQTGCYNTRSVADMKRDIEAYADHFG--VQGIFFDEAATDPMQRSFYQELSNHARSLGLP--LMVLNPGITPDASY--------VSNDAVAHSAVT--FESSYAEWLQAIK---------PDDWSQTTAARQSALLVYDVPADALQAVVDQALQW--------NYGYLYFTDD--GNDGNPWDSLPTYWNTLL 486          
The following BLAST results are available for this feature:
BLAST of mRNA_L-elsbetiae_contig733.16203.1 vs. uniprot
Analysis Date: 2022-09-16 (Diamond blastp: OGS1.0 vs UniRef90)
Total hits: 25
Match NameE-valueIdentityDescription
A0A6H5L2B5_9PHAE4.840e-14968.47Uncharacterized protein n=1 Tax=Ectocarpus sp. CCA... [more]
D7FXS0_ECTSI9.730e-9770.68Uncharacterized protein n=1 Tax=Ectocarpus silicul... [more]
SR4_PHYPO3.290e-1938.01Spherulin-4 n=1 Tax=Physarum polycephalum TaxID=57... [more]
A0A8K0UW06_9AGAM3.740e-1932.33Spherulation-specific family 4-domain-containing p... [more]
A0A522XYQ4_9ARCH1.440e-1831.62Uncharacterized protein n=1 Tax=Candidatus Nitroso... [more]
A0A1Q7L1P0_9ARCH1.650e-1731.89Fibronectin type-III domain-containing protein (Fr... [more]
A0A074XJD8_AURPU1.280e-1630.48Uncharacterized protein n=17 Tax=Aureobasidium pul... [more]
A0A533WNY1_9ARCH3.030e-1628.81Uncharacterized protein n=1 Tax=Thaumarchaeota arc... [more]
A0A1Q7X933_9ARCH1.870e-1528.88Uncharacterized protein (Fragment) n=1 Tax=Thaumar... [more]
A0A1Y1QAK3_9GAMM3.430e-1530.18Uncharacterized protein n=1 Tax=Thiothrix lacustri... [more]

Pages

back to top
InterPro
Analysis Name: InterProScan on OGS1.0
Date Performed: 2022-09-29
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR021986Spherulation-specific family 4PFAMPF12138Spherulin4coord: 80..331
e-value: 1.2E-32
score: 113.4
IPR021986Spherulation-specific family 4PANTHERPTHR35040FAMILY NOT NAMEDcoord: 75..331

Alignments
The following features are aligned
Aligned FeatureFeature TypeAlignment Location
L-elsbetiae_contig733contigL-elsbetiae_contig733:7906..25875 +
Analyses
This polypeptide is derived from or has results from the following analyses
Analysis NameDate Performed
InterProScan on OGS1.02022-09-29
Diamond blastp: OGS1.0 vs UniRef902022-09-16
OGS1.0 of Laminarionema elsbetiae ELsaHSoW152021-02-24
Relationships

This polypeptide derives from the following mRNA feature(s):

Feature NameUnique NameSpeciesTypePosition
mRNA_L-elsbetiae_contig733.16203.1mRNA_L-elsbetiae_contig733.16203.1Laminarionema elsbetiae ELsaHSoW15mRNAL-elsbetiae_contig733 7722..26170 +


Sequences
The following sequences are available for this feature:

polypeptide sequence

>prot_L-elsbetiae_contig733.16203.1 ID=prot_L-elsbetiae_contig733.16203.1|Name=mRNA_L-elsbetiae_contig733.16203.1|organism=Laminarionema elsbetiae ELsaHSoW15|type=polypeptide|length=482bp
MPVPVRPRDFPMGSSRAKEDVVEQLPARRRSSLSSRRIHGSMLTRKNNEP
GMQAPVAMLLMMGLAACTCRVSAQPVEQLRVLVPLYARPEGDFWKFMVES
GHNSTVSFSVVINPNSGPGDSPEEVYTTGMNDLIEAGVEVLCYVPTGFGT
TDVPTVTADIDTYESFYPQLCGGYFFDEGPGLEEGTWKYTDYYSHVQAVS
GPGSTVVINPGIPPHESLYNVADRYAIDNPNMGGQLVVTSFENKFERFYD
GSQDFRNMEVPFPPRYLQDRYLHSALVYAAYFATLEEFLEWTVFQLFCAN
WGYVFFTDDSFGEDGNPWDELPSYFAQLLAAAAKAPESAGECGTFAPTTA
PTAAPTFAPLAPGETRPPLPILPTPSPTELSTPPPAAIGETRAPSVLPPT
PAPTPSPTPSPTAAPTVMPTMHPTAMPTPVPTPVPVTAAPVSISGAPRRG
CSSSFSSPATLLSGAALLATVFCHGYGVPLL*
back to top
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR021986Spherulin4